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JAK/STAT Signaling Pathway

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Growth Hormones Growth Hormones Receptors Cytokines or Growth Factor Cytokines or Growth Factor Receptor Feedback Inhibition JAK2 SHC1 GRB2 SOCS SOCS, CISH CISH ,Pim-1 c-Myc Cytokines Growth Factors RAS p120 Ras-GAP RAF MAP2K1/2 PI3K MTOR MCL1 MCL1, Apoptosis ERK1/2 JAKs SOCS3 SH-PTP2 SH-PTP1 JAKs JAK2 c-SRC STATs STATs STATs STATs STATs STATs STAT5 STAT5 STAT3 STAT3 STAT3 STAT5 AKT PTP PIAS Gene Expression
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