Elab Fluor® Red 780 Anti-Mouse CD8a Antibody[53-6.7] (无库存)
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- 应用性: FCM
- 亚型: Rat IgG2a, κ
- 宿主: Rat
Background | CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck. |
Alternate Names | T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL; |
Swissprot | |
Gene ID | |
Clone No | |
Host | Rat |
Reactivity | Mouse |
Application | |
Isotype | Rat IgG2a, κ |
Isotype Control | |
Conjugation | Elab Fluor®Red 780 |
Conjugation Information | Elab Fluor® Red 780 is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 770 nm (e.g., a 780/60 nm bandpass filter). |
Spectrum | |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
Expiration date | 12个月 |
Shipping |
冰袋 |
Q1:Are CD8 and CD8α the same index?
Yes they are. CD8 and CD8α are widely used markers for identifying cytotoxic T lymphocytes (CTLs). CD8 plays an important role in mediating the recognition and excution funtions of CTLs. CD8α is a subunit of CD8 complex, which means the α chain, and it is quite important in the formation of the complex. CD8α chain not only participates in the binding with MHC-I molecules, but also regulates the activity of CTLs by interacting with other signal molecules. Therefore, the expression level and functional status of CD8α can be used for evaluating the activation and effection of CTLs, as well as CD8.