Lamin B1 Polyclonal Antibody

Verified Samples in WB:HepG2,Rat heart,Mouse kidney,Rat brain,Mouse lung,Mouse spleen
Verified Samples in IHC:Human breast cancer,Mouse liver,Human uterus,Human liver
Verified Samples in IF: HepG2

WB 1:250-1:500, IHC 1:200-1:600

1:1000

1:5000

2h

Polyclonal

IgG

Recombinant Rat Lamin-B1 protein expressed by E.coli

Lamin B1

ADLD;lamin B1;Lamin-B1;LMN;LMN2;LMNB;Lmnb1;LMNB1;MGC111419;OTTHUMP00000159218抗体

67 kDa

72 kDa

Nucleus inner membrane.

0.3mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Antigen Affinity Purification

Cancer; Cell Biology; Signal Transduction; Tags and Cell Markers

Unconjugated

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).