LE/AF Purified Anti-Human CD279/PD-1 Monoclonal Antibody [J116]

  • Flow cytometry antibody-Elabscience
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  • Flow cytometry antibody-Elabscience
  • Flow cytometry antibody-Elabscience
    产品货号:E-AB-F11290

    别称:PD-1, Programmed Death-1

    规格:
    • 50 μg
    • 500 μg
    • 1 mg
    数量:
    - +
    价格: ¥615

    Antigen Information

    Alternate Names PD-1, Programmed Death-1
    Uniprot ID Q15116
    Background Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

    Product Details

    Form Liquid
    Clone No. J116 (See Other Available Formats)
    Host Mouse
    Isotype Mouse IgG1, κ
    Isotype Control LE/AF Purified Mouse IgG1, κ Isotype Control [MOPC-21] [Product E-AB-F097930]
    Reactivity Human
    Application Block, Neut, FCM,IHC,IP (See the Application Description)
    Storage Buffer PBS with 0.05% Proclin300
    Shipping Biological ice pack at 4 ℃
    Stability & Storage Keep as concentrated solution.
    Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
    Centrifuge before opening to ensure complete recovery of vial contents.
    This product is guaranteed up to one year from purchase.

    Recommended Use

    Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.

    References

    1. Francisco LM, Sage PT, and Sharpe AH. 2010. Immunological Rev. 236:219.
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