|Alternate Names||PD-1, Programmed Death-1|
|Background||Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.|
|Clone No.||J116 (See Other Available Formats)|
|Isotype||Mouse IgG1, κ|
|Isotype Control||LE/AF Purified Mouse IgG1, κ Isotype Control [MOPC-21] [Product E-AB-F097930]|
|Application||Block, Neut, FCM,IHC,IP (See the Application Description)|
|Storage Buffer||PBS with 0.05% Proclin300|
|Shipping||Biological ice pack at 4 ℃|
|Stability & Storage||Keep as concentrated solution.|
Store at 2~8℃ and protected from prolonged exposure to light. Do not freeze.
Centrifuge before opening to ensure complete recovery of vial contents.
This product is guaranteed up to one year from purchase.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume or 100 µl of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
|Catalog No.||Product Name|
|E-AB-F1129A||Purified Anti-Human CD279/PD-1 Monoclonal Antibody [J116]|
|E-AB-F1129B||Anti-Human CD279/PD-1 Monoclonal Antibody(Biotin Conjugated) [J116]|
|E-AB-F1129C||Anti-Human CD279/PD-1 Monoclonal Antibody(FITC Conjugated) [J116]|
|E-AB-F1129D||Anti-Human CD279/PD-1 Monoclonal Antibody(PE Conjugated) [J116]|
|E-AB-F1129E||Anti-Human CD279/PD-1 Monoclonal Antibody(APC Conjugated) [J116]|