PE Anti-Human CD45RA Antibody[HI100]
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- 应用性: FCM
- 亚型: Mouse IgG2b, κ
- 宿主: Mouse
Background | CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines. |
Alternate Names | Receptor-type tyrosine-protein phosphatase C;Ptprc;L-CA;Ly-5;T200;CD45; |
Swissprot | |
Gene ID | |
Clone No | |
Host | Mouse |
Reactivity | Human |
Application | |
Isotype | Mouse IgG2b, κ |
Isotype Control | |
Conjugation | PE |
Conjugation Information | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
Spectrum | |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
Expiration date | 12个月 |
Shipping |
冰袋 |
Q1:What is the difference between Human CD45RA and CD45RO?
CD45 is a receptor-type tyrosine phosphatase, also known as cluster of differentiation 45, that affects multiple signaling pathways, including T cell receptor (TCR) and B cell receptor (BCR) by regulating tyrosine phosphorylation levels. CD45 widely exists on the surface of hematopoietic cell membrane and is expressed on all leukocyte. Six isomers have been identified according to their extracellular epitopes, while CD45RA, CD45RB and CD45RO, have been identified on the surface of human cells. Then, two new subgroups of T cells can be identified by using this isomer molecule. CD45RA+ T cells are regarded as naive T cells (Tn) which means they are not stimulated by antigen , while CD45RO+ cells are known as memory T cells (Tm) been stimulated and differentiated by antigen.