PE Anti-Mouse Foxp3 Antibody[3G3]
Price:
Size:
100Tests
50Tests
100Tests×2
- 应用性: ICFCM
- 亚型: Mouse IgG1, κ
- 宿主: Mouse
Background | FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. |
Alternate Names | Forkhead box protein P3;IPEX;JM2;Foxp3; |
Swissprot | |
Gene ID | |
Clone No | |
Host | Mouse |
Reactivity | Mouse |
Application | |
Isotype | Mouse IgG1, κ |
Isotype Control | |
Conjugation | PE |
Conjugation Information | PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter). |
Spectrum | |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
Expiration date | 12个月 |
Shipping |
冰袋 |
C57BL/6 splenocytes are surface stained with APC Anti-Mouse CD4 Monoclonal Antibody followed by fixation and permeabilization using the Foxp3 Staining/Transcription Factor Buffer Set and intracellular staining with PE Anti-Mouse Foxp3 Monoclonal Antibody.
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E-AB-F1238C | FITC Anti-Mouse Foxp3 Antibody[3G3] | 100Tests , 50Tests , 100Tests×2 |
E-AB-F1238E | APC Anti-Mouse Foxp3 Antibody[3G3] | 100Tests , 50Tests , 100Tests×2 |