PER2 Polyclonal Antibody

Verified Samples in IHC:Human thyroid cancer,Human lung cancer

IHC 1:100-1:300

Polyclonal

IgG

Synthetic peptide of human PER2

PER2

Circadian clock protein PERIOD 2;FASPS;FASPS1;hPER 2;hPER2;KIAA0347;OTTHUMP00000164476;PER 2;PER2;PER2;Period 2;Period 2 isoform 1;Period circadian clock 2;Period circadian protein 2;Period circadian protein homolog 2;Period homolog 2 (Drosophila);Period homolog 2;Period;Drosophila;homolog of;2;Period2抗体

Nucleus. Cytoplasm. Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2.

0.6 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Neuroscience; Signal transduction

Unconjugated

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic Nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.