PerCP/Cyanine5.5 Anti-Human CD62L Antibody[HI62L]
Price:
- 应用性： FCM
- 亚型： Mouse IgG2a, κ
- 宿主： Mouse
| Background | CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells. |
| Alternate Names | L-selectin;Sell;CD62antigen-likefamilymemberL;LAM-1;LECAM1;Lymphnodehomingreceptor;Ly-22;CD62L;Lnhr;Ly22; |
| Swissprot | |
| Clone No | |
| Host | Mouse |
| Reactivity | Human |
| Application | |
| Isotype | Mouse IgG2a, κ |
| Isotype Control | |
| Conjugation | PerCP/Cyanine 5.5 |
| Conjugation Information | PerCP/Cyanine5.5 is designed to be excited by the blue laser (488 nm) and detected using an optical filter centered near 675 nm (e.g., a 690/50 nm bandpass filter). |
| Spectrum |  |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Storage | This product can be stored at 2-8°C for 12 months. Do not freeze. |
| Expiration date | 12个月 |
| Shipping |
冰袋 |
| E-AB-F1336Q | Elab Fluor® Violet 450 Anti-Human CD62L Antibody[HI62L] | 100Tests , 20Tests , 100Tests×2 |
Q1:The difference between CD62L and CD62?
CD62L, CD62E, and CD62P are two immune cell surface molecules that belong to the selectin family. CD62L, also known as L-selectin, is a protein in the integrin family that is expressed primarily on the surface of white blood cells. It is involved in regulating the adhesion and migration of white blood cells, especially in inflammation and immune responses. By binding to its ligand, such as PECAM-1 on vascular endothelial cells, CD62L helps leukocyte to roll out of the circulation and migrate specifically to areas such as inflammation sites or lymph nodes. CD62P, also known as P-selectin, is a adhesion molecule that is expressed primarily on endothelial cells and platelets. In the process of inflammation and thrombosis, CD62P on endothelial cells can be expressed rapidly and bind to ligands (such as PSGL-1) on white blood cells to promote mutual adhesion and activation of white blood cells and platelets. CD62E, also known as E-selectin, is an adhesion molecule that is expressed primarily on endothelial cells.
