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Purified Anti-Human CD8a Antibody[OKT-8]

Price: ¥600 ¥192

Size:
100μg 25μg
  • 应用性: FCM
  • 亚型: Mouse IgG2a, κ
  • 宿主: Mouse
Background
CD8a is a 32-34 kD type I glycoprotein. It forms a homodimer (CD8a/a) or heterodimer (CD8a/b) with CD8b. CD8, also known as T8 and Leu2, is a member of the immunoglobulin superfamily found on the majority of thymocytes, a subset of peripheral blood T cells, and NK cells (which express almost exclusively CD8a homodimers). CD8 acts as a co-receptor with MHC class I-restricted T cell receptors in antigen recognition and T cell activation and has been shown to play a role in thymic differentiation. Two domains in CD8a are important for function: the extracellular IgSF domain binds the α3 domain of MHC class I and the cytoplasmic CXCP motif binds the tyrosine kinase p56 Lck.
Alternate Names
T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Swissprot
Gene ID
Clone No
Host
Mouse
Reactivity
Human
Application
Isotype
Mouse IgG2a, κ
Isotype Control
Conjugation
Unconjugated
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide.
Storage
This product can be stored at 2-8°C for 12 months. Do not freeze.
Expiration date
12个月
Shipping
冰袋
E-AB-F11100 AF/LE Purified Anti-Human CD8a Antibody[OKT-8] 500μg , 50μg , 1mg
E-AB-F1110B Biotin Anti-Human CD8a Antibody[OKT-8] 100μg , 25μg
E-AB-F1110C FITC Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110D PE Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110E APC Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110F PerCP Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110G PE/Cyanine5 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110H PE/Cyanine7 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110I PE/Cyanine5.5 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110J PerCP/Cyanine5.5 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110L Elab Fluor® 488 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110M Elab Fluor® 647 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110Q Elab Fluor® Violet 450 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2
E-AB-F1110S Elab Fluor® Red 780 Anti-Human CD8a Antibody[OKT-8] 100Tests , 20Tests , 100Tests×2

Q1:Are CD8 and CD8α the same index?

Yes they are. CD8 and CD8α are widely used markers for identifying cytotoxic T lymphocytes (CTLs). CD8 plays an important role in mediating the recognition and excution funtions of CTLs. CD8α is a subunit of CD8 complex, which means the α chain, and it is quite important in the formation of the complex. CD8α chain not only participates in the binding with MHC-I molecules, but also regulates the activity of CTLs by interacting with other signal molecules. Therefore, the expression level and functional status of CD8α can be used for evaluating the activation and effection of CTLs, as well as CD8.



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