Active CASP3 Monoclonal Antibody
Price:
Size:
120μL
60μL
20μL
- 宿主: Mouse
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC-p;IF
Verified Samples |
Verified Samples in WB:Hela,3T3,Rat brain Verified Samples in IHC:Human liver |
Dilution | WB 1:500-1:1000, IHC 1:100-1:200, IF 1:100-1:200 |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | Recombinant Protein |
Abbre | Active Caspase-3 |
Synonyms | A830040C14Rik;Apopain;CASP-3;CASP3;CASP3;Casp3a;Caspase 3;Caspase 3;apoptosis-related cysteine peptidase;Caspase 3;apoptosis-related cysteine protease;Caspase 3;apoptosis-related cysteine protease a;Caspase-3 subunit p12;CC3;CPP-32;CPP32;CPP32B;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;Protein Yama;SCA 1;SCA-1;SREBP cleavage activity 1;Yama抗体 |
Swissprot | |
Observed MW | 17kDa |
Cellular Localization | Cytoplasm. |
Tissue Specificity | Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.4. |
Purification Method | Protein A purification |
Research Areas | Cancer; Cell Biology; Metabolism; Neuroscience |
Clone No. | Clone:5A2 |
Conjugation | Unconjugated |
Background | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. |
Western Blot analysis of 1) Hela, 2) 3T3, 3) Rat brain with Active CASP3 Monoclonal Antibody
Immunohistochemistry of paraffin-embedded Human liver tissue using Active CASP3 Monoclonal Antibody at dilution of 1:200.
-
Binding characterization of anthraquinone derivatives by stabilizing G-quadruplex DNA leads to an anticancerous activity
IF: 10.183Journal:Molecular Therapy-Nucleic Acids -
First Evidence of the Expression and Localization of Prothymosin α in Human Testis and Its Involvement in Testicular Cancers
IF: 6.064Journal:Biomolecules -
The petroleum ether extract of Brassica rapa L. induces apoptosis of lung adenocarcinoma cells via the mitochondria-dependent pathway
IF: 5.396 -
Nigral and ventral tegmental area lesioning induces testicular and sperm morphological abnormalities in a rotenone model of Parkinson’s disease
IF: 3.292Journal:ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY -
Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson’s disease
IF: 3.263Journal:NEUROTOXICOLOGY -
Cistanche tubulosa phenylethanoid glycosides induce apoptosis in Eca‑109 cells via the mitochondria‑dependent pathway
IF: 1.871Journal:Oncology Letters -
Diabetes Induced Changes in the Expression of Markers for Alveolar Epithelial Type I and II Cells in the Lung of the Albino Rat
IF: 0.444Journal:JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |