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Elab Fluor® 647 Anti-Human CD45RA Antibody[HI100]

Price: ¥2376 ¥1020 ¥2880

Size:
100Tests 20Tests 100Tests×2
  • 应用性: FCM
  • 亚型: Mouse IgG2b, κ
  • 宿主: Mouse
Background
CD45RA is a 205-220 kD single chain type I glycoprotein. It is an exon 4 splice variant of the tyrosine phosphatase CD45. The CD45RA isoform is expressed on resting/naïve T cells, medullary thymocytes, B cells and monocytes. CD45RA enhances both T cell receptor and B cell receptor signaling. CD45 non-covalently associates with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1. CD45 isoform expression can change in response to cytokines.
Alternate Names
Receptor-type tyrosine-protein phosphatase C;Ptprc;L-CA;Ly-5;T200;CD45;
Swissprot
Gene ID
Clone No
Host
Mouse
Reactivity
Human
Application
Isotype
Mouse IgG2b, κ
Isotype Control
Conjugation
Elab Fluor®647
Conjugation Information
Elab Fluor® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter).
Spectrum
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date
12个月
Shipping
冰袋
Human peripheral blood lymphocytes are stained with Elab Fluor® 647 Anti-Human CD45RA Antibody (filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
E-AB-F1052B Biotin Anti-Human CD45RA Antibody[HI100] 100μg , 25μg
E-AB-F1052C FITC Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052D PE Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052E APC Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052F PerCP Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052G PE/Cyanine5 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052H PE/Cyanine7 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052I PE/Cyanine5.5 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052J PerCP/Cyanine5.5 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052L Elab Fluor® 488 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052P PE/Elab Fluor® 594 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2
E-AB-F1052Q Elab Fluor® Violet 450 Anti-Human CD45RA Antibody[HI100] 100Tests , 20Tests , 100Tests×2

Q1:What is the difference between Human CD45RA and CD45RO?

CD45 is a receptor-type tyrosine phosphatase, also known as cluster of differentiation 45, that affects multiple signaling pathways, including T cell receptor (TCR) and B cell receptor (BCR) by regulating tyrosine phosphorylation levels. CD45 widely exists on the surface of hematopoietic cell membrane and is expressed on all leukocyte. Six isomers have been identified according to their extracellular epitopes, while CD45RA, CD45RB and CD45RO, have been identified on the surface of human cells. Then, two new subgroups of T cells can be identified by using this isomer molecule. CD45RA+ T cells are regarded as naive T cells (Tn) which means they are not stimulated by antigen , while CD45RO+ cells are known as memory T cells (Tm) been stimulated and differentiated by antigen.



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