APC Anti-Human CD206/MMR Antibody[15-2]
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- 应用性: FCM
- 亚型: Mouse IgG1, κ
- 宿主: Mouse
Background | Macrophage mannose receptor (MMR) is a 162-175 kD type I membrane protein also known as CD206, MRC1, or mannose receptor (MR). It is a pattern recognition receptor (PRR) that belongs to C-type lectin superfamily. MMR is expressed on macrophages, dendritic cells, and hepatic or lymphatic endothelial cells, but not on monocytes. MMR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine. MMR mediates endocytosis and phagocytosis, induces activation of macrophages and antigen presentation, plays an important role in host defense, and provides a link between innate and adaptive immunity. |
Alternate Names | CLEC13D;CLEC13DL;MRC1L1;MMR;hMR; |
Swissprot | |
Gene ID | |
Clone No | |
Host | Mouse |
Reactivity | Human |
Application | |
Isotype | Mouse IgG1, κ |
Isotype Control | |
Conjugation | APC |
Conjugation Information | APC is designed to be excited by the Red (627-640 nm) laser and detected using an optical filter centered near 660 nm (e.g., a 660/20 nm bandpass filter). |
Spectrum | |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze. |
Expiration date | 12个月 |
Shipping |
冰袋 |
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Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy
IF: 10.435 -
Influence of ultrasound assisted metal-free Fenton reaction on the structural characteristic and immunostimulatory activity of a β-D-glucan isolated from Dictyophora indusiata
IF: 8.025Journal:INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULESPMID:35970367
E-AB-F1161C | FITC Anti-Human CD206/MMR Antibody[15-2] | 100Tests , 20Tests , 100Tests×2 |
Q1:Is it necessary to take fixation/permeabilization operation while detecting CD206?
CD206 is a transmembrane protein, which can be expressed on both side of the cell membrane. With or without permeabilization are both avaliable for CD206 detection as our anti-mouse CD206 flow antibody can bind both side of CD206. Generally it is recommanded to take fixation/permeabilization operation but these two alternative processes can be decided through the experimental design.
Q2:What are the recommendations for flow cytometry of mouse macrophages to detect M1 and M2 type macrophages?
As a recommandation, F4/80 and CD11b are always used for identyfing macrophages of mouse, and CD86 and CD206 can be used for a further seperation for M1 abd M2 respectively. Specific indicators can be determined according to the literature and experimental requirements.