BAP1 Polyclonal Antibody

Verified Samples in IHC:Human esophagus cancer,Human breast cancer

IHC 1:40-1:200

Polyclonal

IgG

Fusion protein of human BAP1

BAP1

BAP 1;Bap1;BAP1;BRCA 1 associated protein 1;BRCA1 associated protein 1;BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase);BRCA1-associated protein 1;Cerebral protein 13;Cerebral protein 6;DKFZp686N04275;FLJ35406;FLJ37180;HUCEP 13;Hucep 6;HUCEP13;Hucep6;KIAA0272;TPDS;Ubiquitin carboxy terminal hydrolase;Ubiquitin carboxyl terminal hydrolase BAP 1;Ubiquitin carboxyl terminal hydrolase BAP1;Ubiquitin carboxyl-terminal hydrolase BAP1;UCHL2抗体

Cytoplasm. Nucleus. Mainly nuclear. Binds to chromatin.

0.8 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Unconjugated

This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.