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BRCA1 Polyclonal Antibody

  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
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  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    产品货号:E-AB-40282

    别称:BRCA 1, BRCA1, BRCA1 DNA repair associated, BRCA1/BRCA2 containing complex subunit 1, BRCAI, BRCC 1, BRCC1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53

    规格:
    • 20μL
    • 60μL
    • 120μL
    • 200μL
    数量:
    - +
    价格: ¥400

    宿主: Rabbit

    反应性: H,M

    应用: IHC,IF

    货期: 现货+顺丰时间

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    Overview

    Synonyms BRCA 1, BRCA1, BRCA1 DNA repair associated, BRCA1/BRCA2 containing complex subunit 1, BRCAI, BRCC 1, BRCC1, Breast and ovarian cancer susceptibility protein 1, Breast Cancer 1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53
    Swissprot P38398
    Source Rabbit
    Reactivity Human,Mouse
    Immunogen Recombinant Human Breast cancer type 1 susceptibility protein(PKSH033832)
    Application IHC(Detection kit: E-IR-R217),IF
    Recommended dilution IHC 1:100-1:200 IF 1:100-1:400
    Concentration 0.6mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Nucleus
    Tissue specificity Isoform 1 and isoform 3 are widely expressed. Isoform 3 is reduced or absent in several breast and ovarian cancer cell lines.
    Isotype IgG
    Purification Antigen Affinity Purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
    Background RCA1,also named as RNF53,plays a central role in DNA repair by facilitating cellular response to DNA repair. It is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair,ubiquitination and transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. It is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is required for FANCD2 targeting to sites of DNA damage. It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. The antibody is specific to BRCA1. BRCA1 appears to produce multiple splice variants. BRCA1 is a nuclear protein with a molecular mass of 220 kDa. The present study describes the isolation and expression of two cDNAs of BRCA1,including a splice variant designated BRCA1D672-4095. BRCA1D672-4095 is generated by exclusion of exon 11 by in-frame splicing and produces a 97 kDa protein. In contrast to BRCA1,BRCA1D672-4095 localizes to the cytoplasm.

    Images

    • Immunohistochemistry of paraffin-embedded Human breast cancer using BRCA1 Polyclonal Antibody at dilution of 1:100

    • Immunohistochemistry of paraffin-embedded Mouse brain using BRCA1 Polyclonal Antibody at dilution of 1:100

    • Immunofluorescence analysis of McF7 cells using BRCA1 Polyclonal Antibody at dilution of 1:100

    • Immunofluorescence analysis of McF7 cells using BRCA1 Polyclonal Antibody at dilution of 1:100

    • Immunofluorescence analysis of U-2OS cells using BRCA1 Polyclonal Antibody at dilution of 1:100

    • Immunofluorescence analysis of U-2OS cells using BRCA1 Polyclonal Antibody at dilution of 1:100

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