BRCA2 Polyclonal Antibody

Verified Samples in WB:Hela,Rat testis,Jurkat,MCF-7,A431
Verified Samples in IHC:Human colon,Human breast
Verified Samples in IF:U-2OS, U-251MG

WB 1:1000-1:3000 , IHC 1:100-1:200, IF 1:100-1:400

Polyclonal

IgG

Recombinant Human Breast cancer type 2 susceptibility protein

BRCA2

BRCA 2; BRCC 2; Breast and ovarian cancer susceptibility gene early onset antibody; BROVCA2; FACD; FAD 1; FANCB; GLM3抗体

384 kDa

384 kDa

Nucleus, Cytoskeleton

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

Antigen Affinity Purification

Cancer; Epigenetics and Nuclear Signaling

Unconjugated

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.