CASP3 Monoclonal Antibody

Verified Samples in IHC:Human prostate,Mouse liver

IHC 1:100-200

Monoclonal

IgG

Synthetic Peptide of Caspase-3

CASP3

A830040C14Rik;Apopain;CASP-3;CASP3;CASP3;Casp3a;Caspase 3;Caspase 3;apoptosis-related cysteine peptidase;Caspase 3;apoptosis-related cysteine protease;Caspase 3;apoptosis-related cysteine protease a;Caspase-3 subunit p12;CC3;CPP-32;CPP32;CPP32B;Cysteine protease CPP32;EC 3.4.22.56;LICE;mldy;OTTHUMP00000165052;OTTHUMP00000165053;OTTHUMP00000165054;PARP cleavage protease;Procaspase3;Protein Yama;SCA 1;SCA-1;SREBP cleavage activity 1;Yama抗体

Cytoplasm.

Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Protein A purification

Cancer; Cell Biology; Metabolism; Neuroscience

Clone:4B8

Unconjugated

Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.