Caspase-3 Polyclonal Antibody

Verified Samples in WB:Jurkat,Jurkat,HeLa,293T,NIH/3T3,Mouse lung
Verified Samples in IF: HeLa

WB 1:500-1:2000, IF 1:50-1:200

Polyclonal

IgG

A synthetic peptide of human Caspase-3 (NP_004337.2).

Caspase-3

CPP32;CPP32B;SCA-1;Active Caspase 3;CASP3;active Caspase-3;Caspase 3;Caspase-3 p12;caspase-3抗体

31kDa

15kDa/35kDa

Cytoplasm.

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity purification

Cancer; Cell Biology; Metabolism; Neuroscience

Unconjugated

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.