Caspase-9 Polyclonal Antibody

Verified Samples in WB:Jurkat,Jurkat,K562,Mouse liver
Verified Samples in IHC:Rat heart,Human tonsil,Human lung cancer,Human liver,Mouse kidney
Verified Samples in IF:NIH/3T3

WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:100

Polyclonal

IgG

Recombinant protein of human Caspase-9

Caspase-9

CASP9;APAF-3;APAF3;ICE-LAP6;MCH6;PPP1R56;caspase-9;casp9;Caspase 9抗体

17kDa/30kDa/36kDa/46kDa

36kDa/46kDa

Cytosol,apoptosome,cytosol,Mitochondrion,Nucleus,Other locations:protein complex

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Affinity purification

Cancer; Cell Biology; Metabolism

Unconjugated

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.