• 本公司产品仅供体外研究使用,不用于临床诊断

E-Cadherin Polyclonal Antibody

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    产品货号:E-AB-40285

    别称:Arc 1,CADH1,Cadherin 1,cadherin 1 type 1 E-cadherin,Cadherin1,CAM 120/80,CD 324,CD324,CD324 antigen,cdh1,CDHE,E-Cad/CTF3,E-cadherin,ECAD,Epithelial cadherin,epithelial calcium dependant adhesion protein,LCAM,Liver cell adhesion molecule,UVO,Uvomorulin

    规格:
    • 20μL
    • 60μL
    • 120μL
    • 200μL
    数量:
    - +
    价格: ¥400

    宿主: Rabbit

    反应性: H

    应用: IHC

    货期: 现货+顺丰时间

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    Overview

    Synonyms Arc 1,CADH1,Cadherin 1,cadherin 1 type 1 E-cadherin,Cadherin1,CAM 120/80,CD 324,CD324,CD324 antigen,cdh1,CDHE,E-Cad/CTF3,E-cadherin,ECAD,Epithelial cadherin,epithelial calcium dependant adhesion protein,LCAM,Liver cell adhesion molecule,UVO,Uvomorulin
    Swissprot P12830
    Source Rabbit
    Reactivity Human
    Immunogen Recombinant Human Cadherin-1 protein(PKSH033816)
    Application IHC(Detection kit: E-IR-R217)
    Recommended dilution IHC 1:100-1:400
    Concentration 1mg/mL

    Properties

    Cellular localization Cell junction. Cell membrane. Endosome. Golgi apparatus>trans-Golgi network. Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
    Tissue specificity Non-neural epithelial tissues.
    Isotype IgG
    Purification Antigen Affinity Purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.05% Proclin300, 50% glycerol, pH7.3.
    Background This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.

    Images

    • Immunohistochemistry of paraffin-embedded Human carcinoma of Colon using E-Cadherin Polyclonal Antibody at dilution of 1:100

    • Immunohistochemistry of paraffin-embedded Human breast cancer using E-Cadherin Polyclonal Antibody at dilution of 1:100

    • Immunohistochemistry of paraffin-embedded Human Placenta using E-Cadherin Polyclonal Antibody at dilution of 1:100(Elabscience® Product Detected by Lifespan).

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