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Elab Fluor^® 488 Anti-Human CD193 Antibody[5E8]

Uniprot : P51677

货号: E-AB-F1303L
应用: FCM
Isotype: Mouse IgG2b, κ
宿主: Mouse

Applications:

说明书

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规格:

20Tests
100Tests
100Tests×2

价格: ￥1380

数量:

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Antigen Details

Alternate Names	CC CKR3, MIP1-alpha receptor like-2, eotaxin receptor,CCR,C-C chemokine receptor type 3
Swissprot	P51677
Gene ID	1232
References	1. Gerard W, et al. 1996. J. Exp. Med. 183:2437. 2. Uguccioni C, et al. 1997. J. Clin. Invest. 100:1137. 3. Sallusto F, et al. 1997. Science. 277:2005. 4. Loetscher P, et al. 2001. J. Biol. Chem. 276:2986.

Product Details

Form	Liquid
Clone No.	5E8 (See Other Available Formats)
Host	Mouse
Isotype	Mouse IgG2b, κ
Isotype Control	Elab Fluor^® 488 Mouse IgG2b, κ Isotype Control[MPC-11] [Product E-AB-F09812L]
Reactivity	Human
Application	FCM (See the Application Description)
Storage Buffer	Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Recommended Use	Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Shipping	Biological ice pack at 4℃
Stability & Storage	Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Conjugation	Elab Fluor^® 488
	Elab Fluor^® 488 is designed to be excited by the Blue laser (488 nm) and detected using an optical filter centered near 520 nm (e.g., a 525/40 nm bandpass filter).

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Background

CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-alpha receptor like-2, and eotaxin receptor, is a member of the G protein-coupled seven transmembrane receptors family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types.

Protocols & Troubleshootings

Related Protocols	流式细胞表面染色步骤
Troubleshooting	流式实验常见问题及解决方案

Alternative Formats

Cat.No.	Product Name	Sizes
E-AB-F1303C	FITC Anti-Human CD193 Antibody[5E8]	20Tests, 100Tests, 100Tests×2
E-AB-F1303D	PE Anti-Human CD193 Antibody[5E8]	20Tests, 100Tests, 100Tests×2
E-AB-F1303E	APC Anti-Human CD193 Antibody[5E8]	20Tests, 100Tests, 100Tests×2
E-AB-F1303G	PE/Cyanine5 Anti-Human CD193 Antibody[5E8]	20Tests, 100Tests, 100Tests×2
E-AB-F1303M	Elab Fluor^® 647 Anti-Human CD193 Antibody[5E8]	20Tests, 100Tests, 100Tests×2
E-AB-F1303Q	Elab Fluor^® Violet 450 Anti-Human CD193 Antibody[5E8]	20Tests, 100Tests, 100Tests×2