本公司产品仅供体外研究使用，不用于临床诊断
本公司产品仅供体外研究使用，不用于临床诊断
| Alternate Names | Slam,Slamf1,CD 150,Signaling lymphocytic activation molecule |
| Swissprot | Q9QUM4 |
| Gene ID | 27218 |
| References |
1. Castro AG, et al. 1999. J. Immunol. 163:5860. (FC, Costim, IP)
2. Forsberg EC, et al. 2005. PLoS Genet. 1:e28. (FC) 3. Terrazas LI, et al. 2005. Int. J. Parasitol. 35:1349. (FC) 4. Cannons JL, et al. 2006. J. Exp. Med. 203:1551. (FC) 5. Umemoto T, et al. 2006. J. Immunol. 177:7733. (FC) 6. Jordan MA, et al. 2007. J. Immunol. 178:1618. (FC, Block) 7. Jung Y, et al. 2007. Blood 110:82. PubMed 8. Pimanda JE, et al. 2007. Proc. Natl. Acad. Sci. USA 104:840. 9. Sugiyama T, et al. 2007. Proc. Natl. Acad. Sci. USA 104:175. 10. Kim I, et al. 2006. Blood 108:737. PubMed 11. Ema H, et al. 2006. Nat Protoc. 1:2979. 12. Fraser ST, et al. 2007. Blood 109:4616. 13. Jung Y, et al. 2008. Stem Cells. 26:2042. 14. Song J, et al. 2010. Blood 115:2592. 15. Cridland SO, et al. 2009. Blood Cell. Mol. Dis. 43:149. (FC) 16. Morita Y, et al. 2010. J. Exp Med. 207:1173. 17. Talaei N, et al. 2015. J. Immunol. 195(10):4623. |
| Form | Liquid |
| Clone No. | TC15-12F12.2 (See Other Available Formats) |
| Host | Rat |
| Isotype | Rat IgG2a, λ |
| Isotype Control | Elab Fluor® 647 Rat IgG2a, λ Isotype Control[B39-4] [Product E-AB-F09742M] |
| Reactivity | Mouse |
| Application | FCM (See the Application Description) |
| Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
| Recommended Use | Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume]. |
| Shipping | Biological ice pack at 4℃ |
| Stability & Storage | Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase. |
| Conjugation | Elab Fluor® 647 |
| Elab Fluor® 647 is designed to be excited by the Red laser (627-640 nm) and detected using an optical filter centered near 670 nm (e.g., a 660/20 nm bandpass filter). | |
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| CD150 is a 75-95 kD member of the immunoglobulin superfamily, also known as SLAM (signaling lymphocyte activation molecule) or IPO-3. CD150, a single chain type I transmembrane molecule, is expressed on thymocytes, T cell subsets, B cells, dendritic cells, and endothelial cells. The expression is upregulated upon activation. CD150 expression has been shown to be maintained on Th1 but not Th2 clones. T regulatory cells express a relatively high level of CD150. Antibodies against CD150 have been shown to augment IFN-γ production by Th1 cells, especially when co-stimulated through the TCR. CD150 associates with the src homology 2-domain-containing protein tyrosine phosphatase SHP-2, and this association is thought to be involved in signal transduction. In combination with CD48, CD150 is a useful marker for hematopoietic stem cell studies. |
| Related Protocols | 流式细胞表面染色步骤 |
| Troubleshooting |
| Cat.No. | Product Name | Sizes |
| E-AB-F1177C | FITC Anti-Mouse CD150 Antibody[TC15-12F12.2] | 50Tests, 100Tests, 100Tests×2 |
| E-AB-F1177D | PE Anti-Mouse CD150 Antibody[TC15-12F12.2] | 50Tests, 100Tests, 100Tests×2 |
| E-AB-F1177E | APC Anti-Mouse CD150 Antibody[TC15-12F12.2] | 50Tests, 100Tests, 100Tests×2 |
| E-AB-F1177M | Elab Fluor® 647 Anti-Mouse CD150 Antibody[TC15-12F12.2] | 50Tests, 100Tests, 100Tests×2 |
| E-AB-F1177UD | PE Anti-Mouse CD150 Antibody[TC15-12F12.2] | 25μg, 100μg |
| E-AB-F1177UE | APC Anti-Mouse CD150 Antibody[TC15-12F12.2] | 25μg, 100μg |
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