HIF1 alpha Polyclonal Antibody

Verified Samples in IHC:Human prostate cancer,Human brain

IHC 1:50-1:200

Polyclonal

IgG

Recombinant protein of human HIF1A

HIF1A

ARNT interacting protein;ARNT-interacting protein;Basic helix loop helix PAS protein MOP1;Basic-helix-loop-helix-PAS protein MOP1;bHLHe78;Class E basic helix-loop-helix protein 78;HIF 1A;HIF 1alpha;HIF-1-alpha;HIF1 A;HIF1 Alpha;HIF1;HIF1-alpha;HIF1A;HIF1A;Hypoxia inducible factor 1 alpha;Hypoxia inducible factor 1 alpha isoform I.3;Hypoxia inducible factor 1 alpha subunit;Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor;Hypoxia inducible factor 1;alpha subunit (basic helix loop helix transcription factor);Hypoxia inducible factor1alpha;Hypoxia-inducible factor 1-alpha;Member of PAS protein 1;Member of PAS superfamily 1;Member of the PAS Superfamily 1;MOP 1;MOP1;PAS domain-containing protein 8;PASD 8;PASD8抗体

Cytoplasm. Nucleus. Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia.

0.6 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism

Unconjugated

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.