HIF1A Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human; Mouse
- 应用性: IHC
Verified Samples |
Verified Samples in IHC:Human colorectal cancer,Human brain |
Dilution | IHC 1:30-1:150 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Fusion protein of human HIF1A |
Abbre | HIF1A |
Synonyms | ARNT interacting protein;ARNT-interacting protein;Basic helix loop helix PAS protein MOP1;Basic-helix-loop-helix-PAS protein MOP1;bHLHe78;Class E basic helix-loop-helix protein 78;HIF 1A;HIF 1alpha;HIF-1-alpha;HIF1 A;HIF1 Alpha;HIF1;HIF1-alpha;HIF1A;HIF1A;Hypoxia inducible factor 1 alpha;Hypoxia inducible factor 1 alpha isoform I.3;Hypoxia inducible factor 1 alpha subunit;Hypoxia inducible factor 1 alpha subunit basic helix loop helix transcription factor;Hypoxia inducible factor 1;alpha subunit (basic helix loop helix transcription factor);Hypoxia inducible factor1alpha;Hypoxia-inducible factor 1-alpha;Member of PAS protein 1;Member of PAS superfamily 1;Member of the PAS Superfamily 1;MOP 1;MOP1;PAS domain-containing protein 8;PASD 8;PASD8抗体 |
Swissprot | |
Cellular Localization | Cytoplasm. Nucleus. Cytoplasmic in normoxia, nuclear translocation in response to hypoxia. Colocalizes with SUMO1 in the nucleus, under hypoxia. |
Concentration | 1.3 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Purification Method | Antigen affinity purification |
Research Areas | Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism |
Conjugation | Unconjugated |
Background | This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. |
Immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using HIF1A Polyclonal Antibody at dilution of 1:45(×200)
Immunohistochemistry of paraffin-embedded Human brain tissue using HIF1A Polyclonal Antibody at dilution of 1:45(×200)
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |