HRAS Polyclonal Antibody

Verified Samples in IHC:Human prostate gland,Human kidney cancer,Human stomach,Mouse colon,Rat colon

IHC 1:100-1:300

Polyclonal

IgG

Recombinant Human GTPase HRas protein

HRAS

C BAS/HAS; C HA RAS1; CTLO; H Ras 1; H RASIDX; HAMSV; HRAS1; Harvey rat sarcoma viral oncogene homolog; K ras; N ras; p19 H RasIDX protein; p21ras; RASH1; Transforming protein p21; vHa RAS抗体

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

0.78mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% Proclin300, 50% glycerol, pH7.3.

Antigen Affinity Purification

Cell Biology; Signal Transduction; Cell Biology; Epigenetics and Nuclear Signaling; Cancer

Unconjugated

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for this gene.