IFN-beta Monoclonal Antibody(Detector)
Price:
- 宿主： Rat
- 反应性： Mouse
- 应用性： ELISA Detector
| Verified Samples |
Verified Samples in ELISA: Recombinant Mouse IFN-beta protein, Cell Lysates |
| Dilution | ELISA Detector 0.1-0.4 μg/mL |
| Clonality | Monoclonal |
| Isotype | Rat IgG1 |
| Immunogen | Recombinant Mouse IFN-beta protein expressed by Mammalian |
| Abbre | IFN-beta |
| Synonyms | IFNB1, IFB, IFF, IFNB, |
| Swissprot | |
| Concentration | 1 mg/mL |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
| Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
| Purification Method | Protein A/G Purification |
| Research Areas | Cancer, Cardiovascular, Immunology |
| Clone No. | 3E12 |
| Conjugation | Unconjugated |
| Background | Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli.Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth. |
| AN002700P | IFN-beta Monoclonal Antibody(Capture) | 100 μg , 25 μg , 1 mg |
