IRF3 Polyclonal Antibody

Verified Samples in WB:Hela,MCF-7,Jurkat,Mouse kidney,Mouse spinal marrow,Mouse brain,Rat kidney,Rat spinal marrow,Rat brain

WB 1:500-1:2000

Polyclonal

IgG

KLH conjugated Synthetic peptide corresponding to Mouse IRF3

IRF3

IIAE7;Interferon regulatory factor 3;IRF 3;IRF-3;IRF3;IRF3;MGC94729抗体

50-55kDa

50kDa

Cytoplasm. Nucleus. Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect. When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm.

1.5 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Epigenetics and Nuclear Signaling; Immunology

Unconjugated

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.