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Leptin/OB Monoclonal Antibody(Detector)

Leptin/OB Monoclonal Antibody(Detector)
  • Leptin/OB Monoclonal Antibody(Detector)
  • Leptin/OB Monoclonal Antibody(Detector)

Price: ¥2100.00 ¥800.00 Inquire

Size:
100 μg 25 μg 1 mg
  • 宿主: Rat
  • 反应性: Human
  • 应用性: ELISA Detector
Verified Samples
Verified Samples in ELISA: Recombinant Human Leptin/OB protein, Human serum, Human plasma
Dilution
ELISA Detector 0.1-0.4 μg/mL
Clonality
Monoclonal
Isotype
Rat IgG2a
Immunogen
Recombinant Human Leptin/OB protein expressed by E.coli
Abbre
Leptin/OB
Synonyms
LEP, Leptin, Obese protein, Obesity factor, OB, OBS
Swissprot
Concentration
1 mg/mL
Storage
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Buffer
Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Purification Method
Protein A/G Purification
Research Areas
Signal Transduction, Neuroscience, Stem Cells, Cardiovascular, Metabolism
Clone No.
7C1
Conjugation
Unconjugated
Background
Key player in the regulation of energy balance and body weight control. Once released into the circulation,has central and peripheral effects by binding lEPR,found in many tissues,which results in the activation of several major signaling pathways.In the hypothalamus,acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides,also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery,increases basal metabolism,influences reproductive function,regulates pancreatic beta-cell function and insulin secretion,is pro-angiogenic for endothelial cell and affects innate and adaptive immunity.In the arcuate nucleus of the hypothalamus,activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides.In addition to its known satiety inducing effect,has a modulatory role in nutrient absorption. In the intestine,reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38,PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption.Acts as a growth factor on certain tissues,through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1,via JAK2-STAT3 pathway,or VEGFA,via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression.Pro-angiogenic,has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs).In innate immunity,modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells.
Sandwich ELISA-Recombinant Human Leptin/OB protein standard curve.Background subtracted standard curve using Leptin/OB antibody(AN001420P)(Capture),Leptin/OB antibody(AN001430P)(Detector) in sandwich ELISA.The reference range value for Recombinant Human Leptin/OB protein is 31.25-20000 pg/mL.
AN001420P Leptin/OB Monoclonal Antibody(Capture) 100 μg , 25 μg , 1 mg


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