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Osteocalcin Monoclonal Antibody(Detector)

Osteocalcin Monoclonal Antibody(Detector)
  • Osteocalcin Monoclonal Antibody(Detector)
  • Osteocalcin Monoclonal Antibody(Detector)

Price: ¥2100.00 ¥800.00 Inquire

Size:
100 μg 25 μg 1 mg
  • 宿主: Mouse
  • 反应性: Rat
  • 应用性: ELISA Detector
Verified Samples
Verified Samples in ELISA: Recombinant Rat Osteocalcin protein, Rat serum, Rat plasma
Dilution
ELISA Detector 0.1-0.4 μg/mL
Clonality
Monoclonal
Isotype
Mouse IgG1
Immunogen
Recombinant Rat Osteocalcin protein expressed by E.coli
Abbre
Osteocalcin
Synonyms
OsteocaLcin, Bone GLa protein (BGP), Gamma-carboxygLutamic acid-containing protein, BgLap, BgLap2
Swissprot
Concentration
1 mg/mL
Storage
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Buffer
Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Purification Method
Protein A/G Purification
Clone No.
7G10
Conjugation
Unconjugated
Background
The carboxylated form is one of the main organic components of the bone matrix,which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium. The uncarboxylated form acts as a hormone secreted by osteoblasts,which regulates different cellular processes,such as energy metabolism,male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation,insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of leydig cells,initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons,initiating a signaling response that prevents neuronal apoptosis in the hippocampus,favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.
Sandwich ELISA-Recombinant Rat Osteocalcin protein standard curve.Background subtracted standard curve using Osteocalcin antibody(AN001510P)(Capture),Osteocalcin antibody(AN001500P)(Detector) in sandwich ELISA.The reference range value for Recombinant Rat Osteocalcin protein is 0.78-50 ng/mL.
AN001510P Osteocalcin Monoclonal Antibody(Capture) 100 μg , 25 μg , 1 mg


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