OxLDL Monoclonal Antibody(Detector)

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- 宿主: Mouse
- 反应性: Human
- 应用性: ELISA Detector
Verified Samples |
Verified Samples in ELISA: Recombinant Human Ox-LDL protein, Human serum, Human plasma |
Dilution | ELISA Detector 0.1-0.4 μg/mL |
Clonality | Monoclonal |
Isotype | Mouse IgG1 |
Immunogen | Human OxLDL Native Protein |
Abbre | OxLDL |
Synonyms | Oxidized LDL, Ox LDL, Ox-LDL |
Concentration | 1 mg/mL |
Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
Purification Method | Protein A/G Purification |
Clone No. | 15F5 |
Conjugation | Unconjugated |
Background | Oxidized lDl (Ox-lDl) is a class of modified lDl. In addition to oxidation-modified lDl,modified lDl also includes acetylated lDl directly combined with malondialdehyde (MDA) and 4-hydroxylenic acid (4-HNE). These lDl which are not oxidation-modified but only chemically modified are called derived lDl. Different from derived lDl,Ox-lDl has unique physiological characteristics in the following aspects: (1) Ox-lDl can affect the metabolism of arachidonic acid and inhibit the esterification of cholesterol,but the derived lDl has no such effect,(2) Ox-lDl consumes endogenous antioxidant substances in lDl and reduces vitamin E content in lDl,while MDA-lDl has no such effect,(3) Oxidative modification involves lipid peroxidation,and PUFAs in lDl are oxidized,(4) When oxidized lDl is low in oxidation degree,ApoB degrades,When the oxidation degree is high,ApoB can be repolymerized. Ox-lDl is not metabolized by lDl receptors,and is recognized,bound,and endocytosed into cells by scavorator receptors. The normal cholesterol metabolism pathway is lost,resulting in intracellular lipid deposition and foam-like transformation. |
AN001320P | OxLDL Monoclonal Antibody(Capture) | 100 μg , 25 μg , 1 mg |