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p16 Polyclonal Antibody

Price: ¥2365 ¥1640 ¥1010 ¥420

Size:
200μL 120μL 60μL 20μL
  • 宿主: Rabbit
  • 反应性: Human;Rat
  • 应用性: IHC;IF
Verified Samples
Verified Samples in IHC:Rat liver,Human ovarian
Verified Samples in IF:PC-3
Dilution
IHC 1:50-1:200 , IF 1:100-1:200
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein
Abbre
p16
Synonyms
CCM2;CDK4 inhibitor p16 INK4;CDK4I;CDKN2;CDKN2A;Cell cycle negative regulator beta;CMM2;Cyclin dependent kinase 4 inhibitor A;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4);Cyclin Dependent Kinase Inhibitor 2A抗体
Swissprot
Cellular Localization
Cytoplasm,?Nucleus
Concentration
0.82 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.
Purification Method
Antigen Affinity Purification
Research Areas
Cancer; Cell Biology; Epigenetics and Nuclear Signaling
Conjugation
Unconjugated
Background
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Immunohistochemistry of paraffinembedded Rat liver using p16 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffinembedded Human ovarian using p16 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of PC-3 cells using p16 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of PC-3 cells using p16 Polyclonal Antibody at dilution of 1:100


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