p16 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human;Rat
- 应用性: IHC;IF
Verified Samples |
Verified Samples in IHC:Rat liver,Human ovarian Verified Samples in IF:PC-3 |
Dilution | IHC 1:50-1:200 , IF 1:100-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Rat Cyclin-dependent kinase inhibitor 2A protein |
Abbre | p16 |
Synonyms | CCM2;CDK4 inhibitor p16 INK4;CDK4I;CDKN2;CDKN2A;Cell cycle negative regulator beta;CMM2;Cyclin dependent kinase 4 inhibitor A;Cyclin dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4);Cyclin Dependent Kinase Inhibitor 2A抗体 |
Swissprot | |
Cellular Localization | Cytoplasm,?Nucleus |
Concentration | 0.82 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% Proclin300 and 50% glycerol, pH7.4. |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer; Cell Biology; Epigenetics and Nuclear Signaling |
Conjugation | Unconjugated |
Background | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. |
Immunohistochemistry of paraffinembedded Rat liver using p16 Polyclonal Antibody at dilution of 1:100
Immunohistochemistry of paraffinembedded Human ovarian using p16 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of PC-3 cells using p16 Polyclonal Antibody at dilution of 1:100
Immunofluorescence analysis of PC-3 cells using p16 Polyclonal Antibody at dilution of 1:100
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |