• 本公司产品仅供体外研究使用,不用于临床诊断

P53 Monoclonal Antibody

  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
<
>
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
  • monoclonal antibody-Elabscience
    产品货号:E-AB-22015

    别称:Antigen NY-CO-13,BCC7,Cellular tumor antigen p53,FLJ92943,LFS1,Mutant tumor protein 53,p53,p53 tumor suppressor,P53,Phosphoprotein p53,Tp53,Transformation related protein 53,TRP53,Tumor protein 53,Tumor protein p53,Tumor suppressor p53

    规格:
    • 20μL
    • 60μL
    • 120μL
    数量:
    - +
    价格: ¥552

    宿主: Mouse

    反应性: H

    应用: WB,IHC-p,IF

    Overview

    Synonyms Antigen NY-CO-13,BCC7,Cellular tumor antigen p53,FLJ92943,LFS1,Mutant tumor protein 53,p53,p53 tumor suppressor,P53,Phosphoprotein p53,Tp53,Transformation related protein 53,TRP53,Tumor protein 53,Tumor protein p53,Tumor suppressor p53
    Swissprot P04637
    Source Mouse
    Reactivity Human
    Immunogen Synthetic Peptide
    Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R217),IF
    Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:100-1:200
    Concentration 1mg/mL
    Clonality Monoclonal

    Properties

    Cellular localization Cytoplasm; Cytoplasm. Nucleus. Nucleus>PML body. Endoplasmic reticulum. Interaction with BANP promotes nuclear localization. Recruited into PML bodies together with CHEK2; Nucleus. Cytoplasm. Localized in both nucleus and cytoplasm in most cells. In some cells, forms foci in the nucleus that are different from nucleoli; Nucleus. Cytoplasm. Localized in the nucleus in most cells but found in the cytoplasm in some cells; Nucleus. Cytoplasm. Localized mainly in the nucleus with minor staining in the cytoplasm; Nucleus. Cytoplasm. Predominantly nuclear but localizes to the cytoplasm when expressed with isoform 4 and Nucleus. Cytoplasm. Predominantly nuclear but translocates to the cytoplasm following cell stress.
    Tissue specificity Ubiquitous. Isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
    Clone No. Clone:1H4
    Isotype IgG
    Purification Protein A purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.4
    Background Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.

    Images

    • Western Blot analysis of 293T cells using p53 Monoclonal Antibody at dilution of 1) 1:1000 2) 1:2000.

    • Immunohistochemistry of paraffin-embedded Human colon cancer tissue using p53 Monoclonal Antibody at dilution of 1:200.

    • Immunofluorescence analysis of Hela tissue using p53 Monoclonal Antibody at dilution of 1:100.

    写评论得优惠
    • 全部 (0)
    • 评论 (0)
    • 问答 (0)
    ... 展开 收起

    我的购物车

    产品名称 数量 价格
    结算

    总计:

    2019-nCoV 新冠病毒相关研究和检测试剂

    浏览历史


      买了该产品的人还买了