请输入货号/产品关键词 !
插入特殊字符:
  • α
  • β
  • γ
  • δ
  • ε
  • ζ
  • η
  • θ
  • κ
  • μ
  • ω
  • σ
  • τ
  • λ
  • ⅩⅢ
  • ⅩⅢ
  • ⅩⅣ
  • ⅩⅤ
  • ⅩⅦ
  • ⅩⅧ
  • 收起 ↑
热门搜索: 最新活动 文献引用 新品速递 一步法ELISA 流式抗体 铜死亡 Annexin V凋亡检测 TUNEL凋亡检测 未包被ELISA 铁死亡 双硫死亡

PE Anti-Human CD45RO Antibody[UCHL1]

Price: ¥1152 ¥384 ¥1872

Size:
100Tests 20Tests 100Tests×2
  • 应用性: FCM
  • 亚型: Mouse IgG2a, κ
  • 宿主: Mouse
Background
CD45RO is a 180 kD single chain membrane glycoprotein. It is a splice variant of tyrosine phosphatase CD45, lacking the A, B, and C determinants. The CD45RO isoform is expressed on activated and memory T cells, some B cell subsets, activated monocytes/macrophages, and granulocytes. CD45RO enhances both T cell receptor and B cell receptor signaling mediated activation. CD45 and its isoforms non-covalently associate with lymphocyte phosphatase-associated phosphoprotein (LPAP) on T and B lymphocytes. CD45 has been reported to be associated with several other cell surface antigens including CD1, CD2, CD3, and CD4. CD45 has also been reported to bind galectin-1 and CD22. CD45 isoform expression can change in response to cytokines.
Gene ID
Clone No
Host
Mouse
Reactivity
Human
Application
Isotype
Mouse IgG2a, κ
Isotype Control
Conjugation
PE
Conjugation Information
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
Spectrum
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date
12个月
Shipping
冰袋
Human peripheral blood lymphocytes are stained with PE Anti-Human CD45RO Antibody (filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
E-AB-F1139C FITC Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139E APC Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139F PerCP Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139G PE/Cyanine5 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139H PE/Cyanine7 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139I PE/Cyanine5.5 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139J PerCP/Cyanine5.5 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139L Elab Fluor® 488 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139M Elab Fluor® 647 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2
E-AB-F1139P PE/Elab Fluor® 594 Anti-Human CD45RO Antibody[UCHL1] 100Tests , 20Tests , 100Tests×2

Q1:What is the difference between Human CD45RA and CD45RO?

CD45 is a receptor-type tyrosine phosphatase, also known as cluster of differentiation 45, that affects multiple signaling pathways, including T cell receptor (TCR) and B cell receptor (BCR) by regulating tyrosine phosphorylation levels. CD45 widely exists on the surface of hematopoietic cell membrane and is expressed on all leukocyte. Six isomers have been identified according to their extracellular epitopes, while CD45RA, CD45RB and CD45RO, have been identified on the surface of human cells. Then, two new subgroups of T cells can be identified by using this isomer molecule. CD45RA+ T cells are regarded as naive T cells (Tn) which means they are not stimulated by antigen , while CD45RO+ cells are known as memory T cells (Tm) been stimulated and differentiated by antigen.



微信客服 微信客服 在线留言 TOP