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PE Anti-Human CD62L Antibody[DREG56]

Price: ¥1296 ¥456 ¥1987.2

Size:
100Tests 20Tests 100Tests×2
  • 应用性: FCM
  • 亚型: Mouse IgG1, κ
  • 宿主: Mouse
Background
CD62L is a 74-95 kD single chain type I glycoprotein referred to as L-selectin or LECAM-1. It is expressed on most peripheral blood B cells, subsets of T and NK cells, monocytes, granulocytes, and certain hematopoietic malignant cells. CD62L binds to carbohydrates present on certain glycoforms of CD34, glycam-1, and MAdCAM-1 and with a low affinity to anionic oligosaccharide sequences related to sialylated Lewis X (sLex, CD15s) through its C-type lectin domain. CD62L is important for the homing of naïve lymphocytes to high endothelial venules in peripheral lymph nodes and Peyer's patches. It also plays a role in leukocyte rolling on activated endothelial cells.
Alternate Names
L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Swissprot
Gene ID
Clone No
Host
Mouse
Reactivity
Human
Application
Isotype
Mouse IgG1, κ
Isotype Control
Conjugation
PE
Conjugation Information
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
Spectrum
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date
12个月
Shipping
冰袋
Human peripheral blood lymphocytes are stained with PE Anti-Human CD62L Antibody (filled gray histogram). Unstained lymphocytes (empty black histogram) are used as control.
E-AB-F1051A Purified Anti-Human CD62L Antibody[DREG56] 100μg , 25μg
E-AB-F1051B Biotin Anti-Human CD62L Antibody[DREG56] 100μg , 25μg
E-AB-F1051C FITC Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051E APC Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051G PE/Cyanine5 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051H PE/Cyanine7 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051J PerCP/Cyanine5.5 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051L Elab Fluor® 488 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051M Elab Fluor® 647 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051P PE/Elab Fluor® 594 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051Q Elab Fluor® Violet 450 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2
E-AB-F1051S Elab Fluor® Red 780 Anti-Human CD62L Antibody[DREG56] 100Tests , 20Tests , 100Tests×2

Q1:The difference between CD62L and CD62?

CD62L, CD62E, and CD62P are two immune cell surface molecules that belong to the selectin family. CD62L, also known as L-selectin, is a protein in the integrin family that is expressed primarily on the surface of white blood cells. It is involved in regulating the adhesion and migration of white blood cells, especially in inflammation and immune responses. By binding to its ligand, such as PECAM-1 on vascular endothelial cells, CD62L helps leukocyte to roll out of the circulation and migrate specifically to areas such as inflammation sites or lymph nodes. CD62P, also known as P-selectin, is a adhesion molecule that is expressed primarily on endothelial cells and platelets. In the process of inflammation and thrombosis, CD62P on endothelial cells can be expressed rapidly and bind to ligands (such as PSGL-1) on white blood cells to promote mutual adhesion and activation of white blood cells and platelets. CD62E, also known as E-selectin, is an adhesion molecule that is expressed primarily on endothelial cells.



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