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PE Anti-Mouse Foxp3 Antibody[3G3]

Price: ¥2736 ¥1728 ¥4104

Size:
100Tests 50Tests 100Tests×2
  • 应用性: ICFCM
  • 亚型: Mouse IgG1, κ
  • 宿主: Mouse
Background
FOXP3 is a 50-55 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in 'scurfy' mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3) corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2.
Alternate Names
Forkhead box protein P3;IPEX;JM2;Foxp3;
Swissprot
Gene ID
Clone No
Host
Mouse
Reactivity
Mouse
Application
Isotype
Mouse IgG1, κ
Isotype Control
Conjugation
PE
Conjugation Information
PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
Spectrum
Storage Buffer
Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA.
Storage
This product can be stored at 2-8°C for 12 months. Please protected from prolonged exposure to light and do not freeze.
Expiration date
12个月
Shipping
冰袋
C57BL/6 splenocytes are surface stained with APC Anti-Mouse CD4 Monoclonal Antibody followed by fixation and permeabilization using the Foxp3 Staining/Transcription Factor Buffer Set and intracellular staining with PE Anti-Mouse Foxp3 Monoclonal Antibody.
E-AB-F1238C FITC Anti-Mouse Foxp3 Antibody[3G3] 100Tests , 50Tests , 100Tests×2
E-AB-F1238E APC Anti-Mouse Foxp3 Antibody[3G3] 100Tests , 50Tests , 100Tests×2


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