PIAS3 Polyclonal Antibody

Verified Samples in IHC:Human liver cancer,Human ovarian cancer

IHC 1:40-1:200

Polyclonal

IgG

Synthetic peptide of human PIAS3

PIAS3

E3 SUMO protein ligase PIAS 3;E3 SUMO protein ligase PIAS3;E3 SUMO-protein ligase PIAS3;FLJ14651;OTTHUMP00000015586;OTTHUMP00000015587;PIAS 3;Pias3;PIAS3 protein;PIAS3;Protein inhibitor of activated STAT 3;Protein inhibitor of activated STAT protein 3;Protein inhibitor of activated STAT3;Zinc finger MIZ type containing 5;ZMIZ 5;ZMIZ5抗体

Cytoplasm. Nucleus. Nucleus speckle. Colocalizes with MITF in the nucleus. Colocalizes with GFI1 in nuclear dots. Colocalizes with SUMO1 in nuclear granules.

1.1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.05% NaN3 and 40% Glycerol,pH7.4

Antigen affinity purification

Cancer; Cell Biology; Epigenetics and Nuclear Signaling

Unconjugated

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined.