PKC zeta Polyclonal Antibody

Verified Samples in WB:COS-7

WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000

Polyclonal

IgG

Synthesized peptide derived from human PKC ζ around the non-phosphorylation site of Thr560.

PKC ζ

14-3-3-zetaisoform;AI098070;aPKCzeta;C80388;EC 2.7.11.13;KPCZ;nPKC zeta;nPKC-zeta;OTTHUMP00000001368;OTTHUMP00000044160;PKC 2;PKC ZETA;PKC2;Pkcz;PKCZETA;PKM-zeta;included;PRKCZ;Protein kinase C zeta;Protein kinase C zeta form;Protein kinase C zeta type;r14-3-3;R74924;zetaPKC抗体

68kDa

80kDa

Cytoplasm. Endosome. Cell junction. In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.

1 mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Affinity purification

Cancer; Signal Transduction

Unconjugated

This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Phosphorylates 'Ser-311' of RELA subunit of NF-kappa-B.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.