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PKC zeta Polyclonal Antibody

  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
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  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
  • polyclonal antibody-Elabscience
    产品货号:E-AB-32609

    别称:14-3-3-zetaisoform,AI098070,aPKCzeta,C80388,EC 2.7.11.13,KPCZ,nPKC zeta,nPKC-zeta,OTTHUMP00000001368,OTTHUMP00000044160,PKC 2,PKC ZETA,PKC2,Pkcz,PKCZETA,PKM-zeta,included,PRKCZ,Protein kinase C zeta,Protein kinase C zeta form,Protein kinase C zeta type,r14-3-3,R74924,zetaPKC

    规格:
    • 20μL
    • 60μL
    • 120μL
    • 200μL
    数量:
    - +
    价格: ¥400

    宿主: Rabbit

    反应性: H,M,R,Mk

    应用: WB,IHC-p,IF,ELISA

    Overview

    Synonyms 14-3-3-zetaisoform,AI098070,aPKCzeta,C80388,EC 2.7.11.13,KPCZ,nPKC zeta,nPKC-zeta,OTTHUMP00000001368,OTTHUMP00000044160,PKC 2,PKC ZETA,PKC2,Pkcz,PKCZETA,PKM-zeta,included,PRKCZ,Protein kinase C zeta,Protein kinase C zeta form,Protein kinase C zeta type,r14-3-3,R74924,zetaPKC
    Swissprot Q05513
    Source Rabbit
    Reactivity Human,Mouse,Rat,Monkey
    Immunogen Synthesized peptide derived from human PKC ζ around the non-phosphorylation site of Thr560.
    Application WB(Detection kit: E-IR-R304),IHC-p(Detection kit: E-IR-R217),IF,ELISA
    Recommended dilution WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
    Concentration 1mg/mL
    Clonality Polyclonal

    Properties

    Cellular localization Cytoplasm. Endosome. Cell junction. In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.
    Tissue specificity Expressed in brain, and to a lesser extent in lung, kidney and testis.
    Isotype IgG
    Purification Affinity purification
    Conjugation Unconjugated
    Storage instructions Store at -20℃. Avoid freeze / thaw cycles.
    Storage buffer PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
    Background This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Phosphorylates 'Ser-311' of RELA subunit of NF-kappa-B.PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.

    Images

    • Western Blot analysis of COS7 cells treated with PMA (125ng/ml, 30mins) minus immunising peptide using PKC zeta Polyclonal Antibody at dilution of 1:2000.

    客户发表文献

    1. Pkcζ In Prostate Cancer Cells Represses The Recruitment And M2 Polarization Of Macrophages In The Prostate Cancer Microenvironment.
      IF: 3.65
      Journal: Tumor Biology(2017)
      DOI: 10.1177/1010428317701442
      PMID: 28631559
      引用产品: E-AB-32609 E-EL-H0101c E-EL-H0103c 
      样本类型: Cell culture supernatant,Cell lysate
      物种: Human
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