PKM Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC
Verified Samples |
Verified Samples in WB: Hela Verified Samples in IHC: Human lung cancer |
Dilution | WB 1:500-1:2000, IHC 1:50-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant protein of human PKM2 |
Abbre | PKM2 |
Synonyms | CTHBP, Cytosolic thyroid hormone binding protein, Cytosolic thyroid hormone-binding protein, KPYM, MGC3932, OIP 3, OIP-3, OIP3, OPA interacting protein 3, Opa-interacting protein 3, PK, PK muscle type, PK2, PK3, PKM, PKM2, Pyruvat, Pyruvate kinase 2/3, muscle type, p58, pykm |
Swissprot | |
Calculated MW | 58 kDa |
Cellular Localization | Cytoplasm. Nucleus. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity. |
Concentration | 0.6 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% sodium azide and 50% glycerol, pH 7.4. |
Purification Method | Affinity purification |
Research Areas | Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction |
Conjugation | Unconjugated |
Background | This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. |
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Testosterone regulates thymic remodeling by altering metabolic reprogramming in male rats
IF: 2.700Journal: GENERAL AND COMPARATIVE ENDOCRINOLOGY (2024)PMID:38191062Reactivity:RatSample Type:thymus
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E-AB-1043 | Streptavidin(peroxidase/HRP conjugated) | 500 μL , 120 μL , 60 μL , 30 μL , 1 mL |
E-AB-1194 | HRP-Goat Anti-Rabbit IgG(H+L) preadsorbed | 500 μL , 120 μL , 1 mL |
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 50 mL , 18 mL , 6 mL , 3 mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50 Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50 Assays |