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PKM Polyclonal Antibody

PKM Polyclonal Antibody
  • PKM Polyclonal Antibody
  • PKM Polyclonal Antibody
  • PKM Polyclonal Antibody

Price: ¥2365.00 ¥1640.00 ¥1010.00 ¥420.00

Size:
200 μL 120 μL 60 μL 20 μL
  • 宿主: Rabbit
  • 反应性: Human;Mouse;Rat
  • 应用性: WB;IHC
Verified Samples
Verified Samples in WB: Hela
Verified Samples in IHC: Human lung cancer
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Clonality
Polyclonal
Isotype
IgG
Immunogen
Recombinant protein of human PKM2
Abbre
PKM2
Synonyms
CTHBP, Cytosolic thyroid hormone binding protein, Cytosolic thyroid hormone-binding protein, KPYM, MGC3932, OIP 3, OIP-3, OIP3, OPA interacting protein 3, Opa-interacting protein 3, PK, PK muscle type, PK2, PK3, PKM, PKM2, Pyruvat, Pyruvate kinase 2/3, muscle type, p58, pykm
Swissprot
Calculated MW
58 kDa
Cellular Localization
Cytoplasm. Nucleus. Translocates to the nucleus in response to different apoptotic stimuli. Nuclear translocation is sufficient to induce cell death that is caspase independent, isoform-specific and independent of its enzymatic actvity.
Concentration
0.6 mg/mL
Storage
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Buffer
PBS with 0.05% sodium azide and 50% glycerol, pH 7.4.
Purification Method
Affinity purification
Research Areas
Cancer, Epigenetics and Nuclear Signaling, Metabolism, Signal Transduction
Conjugation
Unconjugated
Background
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis.
Western Blot analysis of Hela cell using PKM Polyclonal Antibody at dilution of 1:500
Immunohistochemistry of paraffin-embedded Human lung cancer using PKM Polyclonal Antibody at dilution of 1:50


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