Progranulin/PGRN Polyclonal Antibody(Capture/Detector)

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- 宿主: Rabbit
- 反应性: Human
- 应用性: ELISA Capture/Detector
Verified Samples |
Verified Samples in ELISA: Recombinant Human Progranulin/PGRN protein, Human serum, Human plasma |
Dilution | ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Immunogen | Recombinant Human Progranulin/PGRN protein expressed by Mammalian |
Abbre | Progranulin/PGRN |
Synonyms | proepithelin, PC cell-derived growth factor, |
Swissprot | |
Concentration | 1 mg/mL |
Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. |
Buffer | Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300. |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer, Immunology, Neuroscience, Signal transduction |
Conjugation | Unconjugated |
Background | Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
PDMH100103 | Recombinant Human Granulin/PGRN protein (His Tag) | 100 μg , 20 μg |