elabscienceelabscience

全部分类

  • 全部分类
  • 流式抗体
  • ELISA试剂盒
  • 磁珠分选
  • 抗体及相关试剂
  • 细胞状态检测
  • 细胞代谢检测试剂盒
  • 免疫测定试剂盒与试剂
  • 细胞鉴定
  • 蛋白
请输入货号/产品关键词 !
插入特殊字符:
  • α
  • β
  • γ
  • δ
  • ε
  • ζ
  • η
  • θ
  • κ
  • μ
  • ω
  • σ
  • τ
  • λ
  • ⅩⅢ
  • ⅩⅢ
  • ⅩⅣ
  • ⅩⅤ
  • ⅩⅦ
  • ⅩⅧ
  • 收起 ↑
热门搜索: 最新活动 文献引用 新品速递 一步法ELISA 流式抗体 铜死亡 Annexin V凋亡检测 TUNEL凋亡检测 未包被ELISA 铁死亡 双硫死亡

Proprotein Convertase 9/PCSK9 Monoclonal Antibody(Capture)

Proprotein Convertase 9/PCSK9 Monoclonal Antibody(Capture)
  • Proprotein Convertase 9/PCSK9 Monoclonal Antibody(Capture)
  • Proprotein Convertase 9/PCSK9 Monoclonal Antibody(Capture)

Price: ¥2100.00 ¥800.00 Inquire

Size:
100 μg 25 μg 1 mg
  • 宿主: Mouse
  • 反应性: Human
  • 应用性: ELISA Capture
Verified Samples
Verified Samples in ELISA: Recombinant Human Proprotein Convertase 9/PCSK9 protein, Human serum, Human plasma
Dilution
ELISA Capture 2-8 μg/mL
Clonality
Monoclonal
Isotype
Mouse IgG1
Immunogen
Recombinant Human Proprotein Convertase 9/PCSK9 protein expressed by Mammalian
Abbre
Proprotein Convertase 9/PCSK9
Synonyms
PCSK9, NARC1, PSEC0052, Proprotein convertase subtiLisin/kexin type 9, NeuraL apoptosis-reguLated convertase 1 (NARC-1), Proprotein convertase 9 (PC9), SubtiLisin/kexin-Like protease PC9
Swissprot
Concentration
1 mg/mL
Storage
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Buffer
Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Purification Method
Protein A/G Purification
Research Areas
Signal Transduction, Cardiovascular, Stem Cells, Cell Biology, Metabolism
Clone No.
12C6
Conjugation
Unconjugated
Background
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (lDlR),very low density lipoprotein receptor (VlDlR),apolipoprotein E receptor (lRP1/APOER) and apolipoprotein receptor 2 (lRP8/APOER2),and promotes their degradation in intracellular acidic compartments.Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic lDlR through a clathrin lDlRAP1/ARH-mediated pathway. May prevent the recycling of lDlR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of lDlR leading to its subsequent degradation.Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a lDlR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway.Inhibits epithelial Na+ channel (ENaC)-mediated Na+ absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of lRP8/APOER2 levels and related anti-apoptotic signaling pathways.
Sandwich ELISA-Recombinant Human Proprotein Convertase 9/PCSK9 protein standard curve.Background subtracted standard curve using Proprotein Convertase 9/PCSK9 antibody(AN001270P)(Capture),Proprotein Convertase 9/PCSK9 antibody(AN001280P)(Detector) in sandwich ELISA.The reference range value for Recombinant Human Proprotein Convertase 9/PCSK9 protein is 0.625-400 ng/mL.


微信客服 微信客服 联系我们 TOP