Recombinant SARS-CoV-2 NSP1 Protein (His Tag)
Price:
Size:
50μg
10μg
- 表达系统: E.coli
- 蛋白编码: YP_009725297.1
别称 |
SARS-CoV 2 nsp1;SARS-CoV 2 Leader protein
|
表达系统 |
E.coli
|
序列 |
Met1-Gly180
|
蛋白编码 |
YP_009725297.1
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种属 |
SARS-CoV-2
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计算分子量 |
22.7 kDa
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表观分子量 |
25 kDa
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标签 |
C-His
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纯度 |
> 85 % as determined by reducing SDS-PAGE.
|
内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
|
运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
制剂 |
Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH 8.5.
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复溶方法 |
Not Applicable
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背景 |
The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ~30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close association with cellular membranes. Nsp1 was proved to be able to suppress host gene expression by promoting host mRNA degradation and was involved in cellular chemokine deregulation. This virus evades the host innate immune response in part through the expression of its non-structural protein (nsp) 1, which inhibits both host gene expression and virus- and interferon (IFN)-dependent signaling. Thus, nsp1 is a promising target for drugs, as inhibition of nsp1 would make SARS-CoV more susceptible to the host antiviral defenses.
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实验操作视频
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