Recombinant SARS-CoV-2 Papain-Like Protease Protein
Price:
Size:
50μg
10μg
- 表达系统: E.coli
- 蛋白编码: QHD43415.1
别称 |
Papain-like Protease;PLpro;PL-PRO;pp1a;Replicase polyprotein 1a
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表达系统 |
E.coli
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序列 |
Glu1564-Lys1878
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蛋白编码 |
QHD43415.1
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种属 |
SARS-CoV-2
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计算分子量 |
35.8 kDa
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表观分子量 |
34 kDa
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标签 |
None
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纯度 |
> 95 % as determined by reducing SDS-PAGE.
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内毒素 |
< 1.0 EU per μg of the protein as determined by the LAL method.
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保存条件 |
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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运输条件 |
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
|
制剂 |
Supplied as a 0.2 μM filtered solution of 20mM Tris-HCl, 10 mM 2-Mercaptoethanol, 20% Glycerol, pH 7.5.
|
复溶方法 |
Not Applicable
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背景 |
Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs that would inhibit viral replication and reduce mortality associated with outbreaks of SARS-CoV. PLpro is a cysteine protease located within the non-structural protein 3 (NS3) section of the viral polypeptide. PLPro activity is required to process the viral polyprotein into functional, mature subunits; specifically, PLPro cleaves a site at the amino-terminus of the viral replicase region. In addition to its role in viral protein maturation, PLPro possesses a deubiquitinating and deISGylating activity. In vivo, this protease antagonizes innate immunity by inhibiting IRF3-induced production of type I interferons.
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Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads
IF: 8.039Journal:JOURNAL OF MEDICINAL CHEMISTRY
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