Recombinant Human B2M/β2-MG Protein (His Tag)

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    产品货号:PKSH033837

    别称:B2MG;Beta-2-Microglobulin;Beta 2 Microglobin;Beta 2 microglobulin Precursor;Beta Chain of MHC Class 1 Proteins;Beta Chain of MHC class I molecules;CDABP0092;Hdcma22p;IMD43

    规格:
    • 20µg
    • 100µg
    数量:
    - +
    价格: ¥499

    Expression_host: E.coli

    Accession: P61769-1

    货期: 3天+顺丰周期

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    Overview

    Synonyms B2MG;Beta-2-Microglobulin;Beta 2 Microglobin;Beta 2 microglobulin Precursor;Beta Chain of MHC Class 1 Proteins;Beta Chain of MHC class I molecules;CDABP0092;Hdcma22p;IMD43
    Expression host E.coli
    Accesstion P61769-1
    Species Human
    Application Immunogen(E-AB-40351, Positive Control)
    Mol_Mass 11.73kDa
    AP_Mol_Mass 13.1kDa
    Tag N-His

    Properties

    Form Liquid
    Purity >90 % as determined by reducing SDS-PAGE.
    Endotoxin Not tested.
    Storage Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
    Shipping This product is provided as lyophilized powder which is shipped with ice packs.
    Formulation Supplied as sterile PBS,25% glycerol,PH7.4
    Reconstitution Please refer to the printed manual for detailed information.
    Protein construction A DNA sequence encoding the Human B2M/β2-MG (P61769-1) (Ile21-Met119) was expressed with a polyhistidine tag at the N-terminus.
    Expression region Ile21-Met119

    Background

    β-2-Microglobulin (B2M) is a secreted protein with 1 Ig-like C1-type (immunoglobulin-like) domain which belongs to the beta-2-microglobulin family. B2M component of major histocompatibility complex (MHC) class I molecules, involved in the presentation of peptide antigens to the immune system. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. B2M is a protein found on the surface of many cells and plentiful on the surface of white blood cells. Serum B2M concentration is increased in renal diseases, various malignant diseases and some inflammatory and autoimmune disorders. B2M may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. B2M has been shown as a marker for monitoring inflammatory disease activity and it appears likely to have a destructive role in amyloidosis-related arthritis. B2M might be involved in the OA (osteoarthritis) pathogenesis. Defects in B2M are the cause of hypercatabolic hypoproteinemia. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. B2M could be a potential therapeutic target in ovarian cancer.

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