S100B Polyclonal Antibody

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- 宿主: Rabbit
- 反应性: Rat
- 应用性: IHC
Verified Samples |
Verified Samples in IHC: Rat brain |
Dilution | IHC 1:2000-1:4700 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Recombinant Human S100B protein expressed by E.coli |
Abbre | S100B |
Synonyms | NEF, Protein S100 B, Protein S100-B, S 100 calcium binding protein beta chain, S 100 protein beta chain, S-100 protein beta chain, S-100 protein subunit beta, S100, S100 calcium binding protein beta (neural), S100 calcium-binding protein B, S100 protein beta chain |
Swissprot | |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% proclin 300, 1% protective protein and 50% glycerol,pH7.4 |
Purification Method | Antigen Affinity Purification |
Research Areas | Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Stem cells |
Conjugation | Unconjugated |
Background | S100B is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs and has been implicated in the regulation of cellular activities such as metabolism, motility and proliferation. In the nervous system, S100B is constitutively released by astrocytes into the extracellular space and at nanomolar concentrations, it can promote neurite outgrowth and protect neurons against oxidative stress. Within the central nervous system (CNS), S100B is thought to be a marker for astroglial activation, linking astrocyte dysfunction to schizophrenia. In addition to astrocytes, S100B is released from many cell types, such as, adipocytes, chondrocytes, cardiomyocytes and lymphocytes. Serum S100B represents a new bomarker for mood disorders. |
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