STAT3 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human;Mouse;Rat
- 应用性: WB;IHC-p;IF
Verified Samples |
Verified Samples in WB:3T3 Verified Samples in IHC:Mouse heart |
Dilution | WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Synthesized peptide derived from human Stat3 around the non-phosphorylation site of Ser727. |
Abbre | Stat3 |
Synonyms | 1110034C02Rik;Acute Phase Response Factor;Acute-phase response factor;ADMIO;APRF;AW109958;DNA binding protein APRF;FLJ20882;HIES;MGC16063;Signal transducer and activator of transcription 3 (acute phase response factor);Signal transducer and activator of transcription 3;STAT 3;Stat3;STAT3抗体 |
Swissprot | |
Calculated MW | 88kDa |
Observed MW | 88kDa |
Cellular Localization | Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3. Identified in a complex with LYN and PAG1. |
Concentration | 1 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4 |
Purification Method | Affinity purification |
Research Areas | Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Developmental Biology; Signal Transduction; Stem Cells |
Conjugation | Unconjugated |
Background | Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. |
Western Blot analysis of 3T3 cells using Stat3 Polyclonal Antibody at dilution of 1:2000.
Immunohistochemistry of paraffin-embedded Mouse heart using Stat3 antibody at dilution of 1:50
E-IR-R217 | 2-step plus Poly-HRP Anti Mouse/Rabbit IgG Detection System (with DAB solution) | 18mL , 6mL , 3mL |
E-IR-R220 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH9.0) | 10mL , 3mL |
E-IR-R221 | Super PlusTM Highly Sensitive and Rapid Immunohistochemical Kit (pH6.0) | 10mL , 3mL |
E-IR-R304A | Western Blot Detection Kit | 50Assays |
E-IR-R304B | High Accuracy and Absorbability Western Blot Detection Kit | 50Assays |