elabscienceelabscience

全部分类

  • 全部分类
  • 流式抗体
  • ELISA试剂盒
  • 磁珠分选
  • 抗体及相关试剂
  • 细胞状态检测
  • 细胞代谢检测试剂盒
  • 免疫测定试剂盒与试剂
  • 细胞鉴定
  • 蛋白
请输入货号/产品关键词 !
插入特殊字符:
  • α
  • β
  • γ
  • δ
  • ε
  • ζ
  • η
  • θ
  • κ
  • μ
  • ω
  • σ
  • τ
  • λ
  • ⅩⅢ
  • ⅩⅢ
  • ⅩⅣ
  • ⅩⅤ
  • ⅩⅦ
  • ⅩⅧ
  • 收起 ↑
热门搜索: 最新活动 文献引用 新品速递 一步法ELISA 流式抗体 铜死亡 Annexin V凋亡检测 TUNEL凋亡检测 未包被ELISA 铁死亡 双硫死亡

VEGF R1/Flt-1 Polyclonal Antibody(Capture/Detector)

VEGF R1/Flt-1 Polyclonal Antibody(Capture/Detector)
  • VEGF R1/Flt-1 Polyclonal Antibody(Capture/Detector)
  • VEGF R1/Flt-1 Polyclonal Antibody(Capture/Detector)

Price: ¥2100.00 ¥800.00 Inquire

Size:
100 μg 25 μg 1 mg
  • 宿主: Rabbit
  • 反应性: Human
  • 应用性: ELISA Capture/Detector
Verified Samples
Verified Samples in ELISA: Recombinant Human VEGF R1/Flt-1 protein, Human serum, Human plasma
Dilution
ELISA Capture 2-8 μg/mL, ELISA Detector 0.1-0.4 μg/mL
Clonality
Polyclonal
Isotype
Rabbit IgG
Immunogen
Recombinant Human VEGF R1/Flt-1 protein expressed by E.coli
Abbre
VEGF R1/Flt-1
Synonyms
VEGFR-1, FLT1, Tyrosine-protein kinase receptor FLT(FLT), Tyrosine-protein kinase FRT(FRT), VEGFR1, VascuLar endotheLiaL growth factor receptor 1, Fms-Like tyrosine kinase 1 (FLT-1), VascuLar permeabiLity factor receptor
Swissprot
Concentration
1 mg/mL
Storage
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Buffer
Phosphate buffered solution, pH 7.2, containing 0.05% proclin 300.
Purification Method
Antigen Affinity Purification
Research Areas
Cardiovascular, Signal Transduction, Cancer, Metabolism
Conjugation
Unconjugated
Background
Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA,VEGFB and PGF,and plays an essential role in the development of embryonic vasculature,the regulation of angiogenesis,cell survival,cell migration,macrophage function,chemotaxis,and cancer cell invasion. Acts as a positive regulator of postnatal retinal hyaloid vessel regression. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation,survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells,proliferation of some types of cancer cells,but does not promote proliferation of normal fibroblasts (in vitro). Has very high affinity for VEGFA and relatively low protein kinase activity,may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. ligand binding leads to the activation of several signaling cascades. Activation of PlCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1,the regulatory subunit of phosphatidylinositol 3-kinase,leading to activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2,MAPK3/ERK1 and the MAP kinase signaling pathway,as well as of the AKT1 signaling pathway. Phosphorylates SRC and YES1,and may also phosphorylate CBl. Promotes phosphorylation of AKT1 at 'Ser-473'. Promotes phosphorylation of PTK2/FAK1.
Sandwich ELISA-Recombinant Human VEGF R1/Flt-1 protein standard curve.Background subtracted standard curve using VEGF R1/Flt-1 antibody(AN000160P)(Capture),VEGF R1/Flt-1 antibody(AN000160P)(Detector) in sandwich ELISA.The reference range value for Recombinant Human VEGF R1/Flt-1 protein is 31.25-2000 pg/mL.


微信客服 微信客服 联系我们 TOP