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MAPK-JNK Signaling Pathway

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TRADD MAP2K1 MAP3K4 MAPKKKs MAP2K4/7 JNK1/2/3 MAP4K1 MAP3K7 MAPKKs MAP3K5 DLK COT MAP3K10/11 MAPK8IP1/2/3 TAO1/2 TRAF2 DAXX RIPK ABL1 JUN P53 ATF2 HSF1 ELK1 SMAD4 NFATC3 NFATc1 STAT3 MLKs ABL1 JNK JNK GCK PI3K PI3Kγ CRK SOS RAS RAC RAC RHO 12/13 Gβγ CDC42 CDC42 CRKL IRS1 NO 14-3-3 14-3-3 14-3-3 14-3-3 MKPs BAD POSH Bim Tau BAX BAX SHC1 GRB2 Apoptosis Apoptosis Insulin Resistance Transcription Neurond Blarity Mitochondrial Translocation Apoptosis Growth Differentiation Infammation Apoptosis