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P53 Signaling Pathway

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Ub FASLG TRAIL FAS DR4 TNFRSF10B UV lonizing Rediation Chemotherapy Death Receptor Signaling Cytochrome C P53 P53 P53 Bcl-x BAX BAX BAK1 Cyclophilin D BAX BAX Bcl-2 Caspase Cascade Caspase Apoptosis ADGRB1 GADD45 c-Fos CDK2 JNK P38 CSNK1 HIPK2 AKT ATR ATM CAK P CHEK1 P CHEK2 GSK3β BRCA1 PML AC P53 P P P53 AC P53 P AC P53 CBP SIRT HDAC P300 KAT2B PIAS1 HIF1α HIF1α Proteasome Degradation P53 Degradation Hypoxia Cyclin E Cyclin D1 CDK4/6 P RB MDM2 Ub P53 Ub P53 MDM2 E2F E2F P21 CIP TAP1 PTEN PTEN Gene Expression Cell Cycle Progression Angiogenesis Inhibition DNA Repair DNA Damage