BAFFR/TNFRSF13C Polyclonal Antibody

Verified Samples in WB:Rat thymus

WB 1:500-1:1000

Polyclonal

IgG

Recombinant Human BAFFR/TNFRSF13C protein expressed by Mammalian

BAFFR/TNFRSF13C

Tumor necrosis factor receptor superfamily member 13C;B-cell-activating factor receptor;BAFF receptor (BAFF-R);BLyS receptor 3;TNFRSF13C;BAFFR;BR3

19 kDa

38-50 kDa

Membrane

Highly expressed in spleen and lymph node,and in resting B-cells Detected at lower levels in activated B-cells,resting CD4+ T-cells,in thymus and peripheral blood leukocytes

1mg/mL

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

PBS with 0.02% sodium azide,1% protective protein and 50% glycerol,pH7.4

Antigen Affinity Purification

Signal Transduction;Stem Cells

Unconjugated

Tumor necrosis factor receptor superfamily,member 13C (TNFRSF13C) also known as B-cell-activating factor receptor (BAFFR) and CD268 antigen,is a member of the tumor necrosis factor receptor superfamily. BAFF promotes the survival of B cells and is essential for B cell maturation. BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17),transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. BAFF R is highly expressed in spleen,lymph node and resting B cells. It is also expressed at lower levels in activated B cell,in resting CD4+ T cells,in thymus and peripheral blood leukocytes. BAFF knockout mice lack mature B cells. Similarly,A/WySnJ mice that are defective in BAFF-R intracellular signaling also lack mature B cells,suggesting that BAFF R is the critical receptor for BAFF during B lymphopoiesis. It has been proposed that abnormally high levels of BAFFR/TNFRSF13C (CD268) may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells.