CEND1 Polyclonal Antibody
Price:
Size:
200μL
120μL
60μL
20μL
- 宿主: Rabbit
- 反应性: Human; Mouse; Rat
- 应用性: WB;IHC
Verified Samples |
Verified Samples in WB:Mouse brain,Rat brain,Human cerebrum Verified Samples in IHC:Human liver cancer |
Dilution | WB 1:500-1:2000;IHC 1:40-1:200 |
Clonality | Polyclonal |
Isotype | IgG |
Immunogen | Synthetic peptide of human CEND1 |
Abbre | CEND1 |
Synonyms | BM88 ;BM88 antigen;Cell cycle exit and neuronal differentiation 1 ;Cell cycle exit and neuronal differentiation protein 1;FLJ90066;MGC34326抗体 |
Swissprot | |
Calculated MW | 15 kDa |
Observed MW | Refer to figures |
Cellular Localization | Membrane; Single-pass type IV membrane protein. |
Concentration | 0.9 mg/mL |
Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
Buffer | PBS with 0.05% NaN3 and 40% Glycerol,pH7.4 |
Purification Method | Antigen affinity purification |
Research Areas | Cancer; Cell Biology; Neuroscience;Tags and Cell markers |
Conjugation | Unconjugated |
Background | BM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A. |
Western blot analysis of Mouse brain tissue Rat brain tissue and Human cerebrum tissue lysates using CEND1 Polyclonal Antibody at dilution of 1:500
Immunohistochemistry of paraffin-embedded Human liver cancer tissue using CEND1 Polyclonal Antibody at dilution of 1:50(×200)
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