DNase-Ⅰ Polyclonal Antibody
Price:
Size:
100μL
50μL
- 宿主： Rabbit
- 反应性： Human
- 应用性： WB
| Verified Samples |
Verified Samples in WB:Hela |
| Dilution | WB 1:500-1:1000 |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant Human DNase-Ⅰ protein expressed by? Mammalian |
| Abbre | DNase-Ⅰ |
| Synonyms | Deoxyribonuclease-1;Deoxyribonuclease I;DNase I;Dornase alfa;DNASE1;DNL1; DRNI |
| Swissprot | |
| Calculated MW | 31kDa |
| Observed MW | 43kDa |
| Concentration | 1mg/mL |
| Storage | Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. |
| Buffer | PBS with 0.02% sodium azide,50% glycerol pH 7.4 |
| Purification Method | Antigen Affinity Purification |
| Research Areas | Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism |
| Conjugation | Unconjugated |
| Background | DNase1,also known as deoxyribonuclease I and DNL1,is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide,yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3',on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE),an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. |
Western blot with DNase-Ⅰ Polyclonal antibody at dilution of 1:1000.lane 1:Hela whole cell lysate
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